Different response of articular chondrocyte subpopulations to surface motion

Articular Chondrocyte Mechanics at Different Loading Rates

INTRODUCTION Mechanical impact loading is known to cause cell death and to lead to the onset and progression of osteoarthritis [1]. In order to understand why in-situ cells die readily following impact loading but remain unaffected when the same load is applied at a slow rate, we used a Finite Element model of articular cartilage and chondrocytes to study the in-situ cell mechanics, which canno...

Chondrocyte multiplication in osteoarthritic articular cartilage.

Chondrocyte ultrastructure in adult human articular cartilage.

Age changes in the ultrastructure of articular chondrocytes have been studied in detail in mice (Silberberg, Silberberg, and Feir, 1964) and in rabbits (Davies, Barnett, Cochrane, and Palfrey, 1962; Barnett, Cochrane, and Palfrey, 1963). Less has been published concerning the influence of age on cellular ultrastructure in human articular cartilage. This is due partly to the scarcity of suitable...

Tissue Engineered Cartilage with Different Human Chondrocyte Sources: Articular, Auricular and Nasal Septum

Tissue engineering is a new biotechnological field that has emerged recently, providing an alternative to the treatment of damages and defects of human tissues. Amongst the most researched tissues is cartilage. In this study, the general characteristics of chondrocytes derived from three different sources in the body: articular, auricular and nasal septum cartilage, were investigated, looking b...

Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism

INTRODUCTION The pathogenesis of osteoarthritis (OA) is characterized by the production of high amounts of nitric oxide (NO), as a consequence of up-regulation of chondrocyte-inducible nitric oxide synthase (iNOS) induced by inflammatory cytokines. NO donors represent a powerful tool for studying the role of NO in the cartilage in vitro. There is no consensus about NO effects on articular carti...